Week 1 Quiz

A 25-year-old man presents with fatigue and jaundice. His hepatitis B serology shows: HBsAg positive, anti-HBc IgM positive, anti-HBs negative. What is the most likely interpretation?

• Immunity due to vaccination

• Acute hepatitis B infection

• Chronic hepatitis B infection

• Past resolved infection

Which investigation is most specific for diagnosing coeliac disease in a patient with chronic diarrhoea and weight loss?

• Anti-tissue transglutaminase (anti-tTG) IgA antibodies

• Anti-nuclear antibodies (ANA)

• Faecal calprotectin

• Anti-mitochondrial antibodies

A 32-year-old woman with a history of Crohn’s disease presents with abdominal pain and diarrhoea. Which medication is most appropriate for inducing remission in moderate to severe Crohn’s disease?

• Mesalazine

• Prednisolone

• Azathioprine

• Loperamide

Which of the following is a distinguishing histological feature of ulcerative colitis compared to Crohn’s disease?

• Transmural inflammation

• Granuloma formation

• Crypt abscesses

• Skip lesions

A 45-year-old man with a history of alcohol misuse presents with ascites and spider naevi. Which investigation is most useful to confirm the diagnosis of cirrhosis?

• Serum amylase

• Colonoscopy

• Ultrasound abdomen and FibroScan

• Chest X-ray

Which of the following is the first-line management for a patient newly diagnosed with coeliac disease?

• Oral corticosteroids

• Gluten-free diet

• Azathioprine

• High-fibre diet

Which serological marker profile best indicates immunity to hepatitis B due to vaccination?

• HBsAg negative, anti-HBc negative, anti-HBs positive

• HBsAg negative, anti-HBc positive, anti-HBs positive

• HBsAg positive, anti-HBc positive, anti-HBs negative

• HBsAg negative, anti-HBc positive, anti-HBs negative

A 60-year-old obese woman with type 2 diabetes is found to have elevated liver enzymes and hepatomegaly. Which is the most likely underlying pathophysiological process in non-alcoholic fatty liver disease (NAFLD)?

• Autoimmune destruction of hepatocytes

• Accumulation of triglycerides in hepatocytes

• Iron overload

• Biliary obstruction

Which of the following medications is commonly used for maintenance of remission in ulcerative colitis?

• Infliximab

• Mesalazine

• Prednisolone

• Metronidazole

A 28-year-old man with Crohn’s disease develops perianal fistulae. Which medication is most appropriate for treating complex perianal Crohn’s disease?

• Methotrexate

• Infliximab

• Mesalazine

• Loperamide