Cardio Meds Antihypertensives

Which one is a Renin Inhibitor?

• Aliskiren

• Captopril

• Losartan

• Eplerenone

Aliskiren is indicated for

• Hypertension

• Hypotension

• MI

• Nephropathy

• HF

What is the mode of action for Renin Inhibitors (Aliskiren)?

• Inhibits renin

• Prevents angiotensinogen from being activated

• Inhibits the effect of aldosterone

• Reduces reabsorption of sodium and water

• Reduces sympathetic outflow from CNS

Answer explanation

Aliskiren kind of looks like Alice and Karen. Alice and Karen gang up to stop Angie (angiotensinogen).

What are the side effects of Renin Inhibitors (Aliskiren)?

• Hypotension

• Angioedema

• GI upset

• Cough

• Elevated potassium

Renin Inhibitors (Aliskiren) side effect is _____ toxicity.

Monitor for __ for Renin Inhibitors (Aliskiren).

Which of these antihypertensives cause fetal toxicity?

• Renin Inhibitors

• ACE Inhibitors

• Angiotensin 2 Blockers

• Eplerenone

• Methyldopa

ACE Inhibitors end with...

Which are ACE inhibitors?

• Captopril

• Lisinopril

• Metoprolol

• Atenolol

• Clondine

Answer explanation

Playing cards: When you get an ACE you get a thrill, ACE inhibitors end in -pril.

What are the mode of action for ACE inhibitors (Captopril & Lisinopril)?

• Blocks conversion of angiotensin 1 and 2, causing vasodilation

• Blocks action of angiotensin 2, resulting in vasodilation

• Inhibits the effect of aldosterone, which decreases reabsorption of sodium

• Blocks calcium channels in the heart and blood vessels, leading to vasodilation