Drug-Receptor Interactions: Key Definitions and Concepts

What is the first step in the drug-receptor interaction process?

• The drug-receptor system produces a biological response

• The drug binds to the receptor

• The receptor changes conformation

• The ligand is metabolized.

What does the stability of the drug-receptor complex depend on?

• The affinity

• The dissociation constant

• The entropy

• The conformation

Some receptors are solvated proteins that exist similarly in equilibrium.

• True

• False

Drugs A, B, C and D bind to receptor R. Which one has the greatest affinity for R?

Drugs A, B, C and D bind to receptor R. Which one has the greatest affinity for R?

The lower the K_d, the _______ the affinity.

• Lower

• Higher

Rank each of the following non-covalent interaction from strongest to weakest

• Dipolar (3)

• Ionic (1)

• van der Waals (4)

• Ion-dipole (2)

Noncovalent interactions typically bind _______ while covalent interactions typically bind _______.

• Irreversibly, Reversibly

• Reversibly, Irreversibly