Pharmacodynamics Worksheet

Based on the chart, predict the EC50. Dose–response table: Dose (mg) vs % Effective — 1: 0; 5: 36; 10: 59; 20: 72; 30: 98.

• 11 mg

• 22 mg

• 4 mg

• 7.5 mg

When drug concentration is equal to Kd, what is the fractional occupancy?

• 25%

• 50%

• 75%

• 100%

Tags

NGSS.HS-PS1-5

True or false: fractional occupancy is often higher than predicted for an agonist due to downstream amplification.

• True

• False

Which term depends on the dose administered?

• Affinity

• Potency

• Efficacy

• Selectivity

What is the relationship between affinity and potency?

• Higher affinity; less potent

• Lower affinity; less potent

• Higher affinity; more potent

• Lower affinity; more potent

Match the following: Full agonist — select the correct description.

• Binds to the same site on the receptor as the endogenous ligand

• Able to produce maximum response for a given population of receptors

• Binds to a different site on the receptor as the endogenous ligand

• Able to produce a sub-maximal response for a given population of receptors

Match the following: Partial agonist — select the correct description.

• Binds to the same site on the receptor as the endogenous ligand

• Able to produce maximum response for a given population of receptors

• Binds to a different site on the receptor as the endogenous ligand

• Able to produce a sub-maximal response for a given population of receptors

Match the following: Orthosteric agonist — select the correct description.

• Binds to the same site on the receptor as the endogenous ligand

• Able to produce maximum response for a given population of receptors

• Binds to a different site on the receptor as the endogenous ligand

• Able to produce a sub-maximal response for a given population of receptors

Match the following: Allosteric agonist — select the correct description.

• Binds to the same site on the receptor as the endogenous ligand

• Able to produce maximum response for a given population of receptors

• Binds to a different site on the receptor as the endogenous ligand

• Able to produce a sub-maximal response for a given population of receptors

On a dose response curve which drug is considered to be the most potent?

• Furthest right

• Furthest left

• The drugs will have the same potency

• Need more information