MCQs on HIV/AIDS – Community Medicine (NEET Level)

AIDS is characterized by profound immunosuppression primarily due to destruction of which cell type?

• Natural killer cells

• CD4+ T helper cells

• B lymphocytes

• CD8+ T lymphocytes

HIV enters the host cell by binding to CD4 receptors and which co-receptors?

• MHC I and MHC II

• CD28 and CD40

• CCR5 and CXCR4

• IL-2 and IL-4

Early massive depletion of CD4+ T cells in HIV infection occurs mainly in which site?

• Peripheral blood

• Bone marrow

• Spleen

• Gut-associated lymphoid tissue (GALT)

Which best explains the occurrence of opportunistic infections in HIV?

• Direct destruction of pathogens by HIV

• Failure of cell-mediated immunity

• Loss of immune surveillance

• Reduced antibody production only

HIV-associated neoplasms occur mainly because:

• Chemotherapy toxicity

• HIV is directly oncogenic

• Loss of immune surveillance and oncogenic virus reactivation

• Increased antibody production

Which virus is associated with Kaposi sarcoma?

• Hepatitis B virus

• Human herpesvirus-8

• Epstein–Barr virus

• Human papilloma virus

The period between HIV infection and appearance of detectable antibodies is called:

• Carrier state

• Window period

• Incubation period

• Latent period

Which is NOT a major sign in clinical diagnosis of AIDS?

• Persistent cough >1 month

• Chronic diarrhea >1 month

• Weight loss ≥10%

• Prolonged fever >1 month

Which is considered a bridge population in HIV transmission?

• Transgender persons

• Female sex workers

• Men who have sex with men

• Migrant labourers

Dolutegravir inhibits which step of HIV replication?

• Viral budding

• Integration of viral DNA into host genome

• Viral entry

• Reverse transcription