Notch Signaling Pathway | Purpose and Mechanism

The video tutorial explains the notch signaling pathway, a crucial mechanism in cellular processes like proliferation, differentiation, and apoptosis. It describes the roles of notch receptors and ligands, the intercellular signaling mechanism, and the activation process involving mind bomb and ubiquitination. The tutorial covers the cleavage events leading to transcription of target genes and the pathway's downregulation. The lesson concludes with a call to action for viewer engagement.

What are the dual functions of the Notch signaling pathway?

• Sensory hair cell development and arterial network branching

• Cellular proliferation and differentiation

• Tissue growth and cancer, cell death and tumor suppression

• Homeostasis and apoptosis

Which of the following is NOT a Notch receptor in mammals?

• Notch 5

• Notch 4

• Notch 2

• Notch 1

Which family does the ligand Jagged 1 belong to?

• Delta-like protein family

• Jagged protein family

• Notch receptor family

• E3 ubiquitin ligase family

What determines a sending cell in the Notch signaling pathway?

• Presence of Mindbomb protein

• More ligands than Notch receptors

• More Notch receptors than ligands

• Equal number of ligands and receptors

What is the role of the Mindbomb protein in the Notch signaling pathway?

• Activates the Notch receptor

• Ubiquitinates the Delta-like ligand

• Cleaves the Notch intracellular domain

• Translocates to the nucleus

What is the result of the S3 cleavage in the Notch signaling pathway?

• Binding of the ligand to the receptor

• Release of the Notch intracellular domain

• Activation of the Delta-like ligand

• Release of the extracellular domain

Which protein acts as a histone acetylation in the Notch signaling pathway?

• CSL

• Mastermind

• FBW7

• P300