The Mechanism of Insulin Biosynthesis by Pancreatic β-cells

The Mechanism of Insulin Biosynthesis by Pancreatic β-cells

Assessment

Interactive Video

Science, Biology, Chemistry

University

Hard

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The video tutorial explains the process of insulin maturation, detailing the roles of the rough ER and Golgi apparatus. It covers the transformation from preproinsulin to mature insulin, highlighting the importance of signal peptides, disulfide bridges, and the cleavage of the C peptide. The tutorial also discusses the secretion of insulin in response to glucose levels in the blood.

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7 questions

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1.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

What organelles are primarily involved in the maturation of insulin?

Mitochondria and Lysosomes

Rough ER and Golgi Apparatus

Nucleus and Ribosomes

Smooth ER and Peroxisomes

2.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

What is the initial form of insulin produced by the ribosome?

Mature Insulin

Proinsulin

Preproinsulin

C-peptide

3.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

Which process is necessary for the formation of disulfide bridges in insulin?

Reduction

Oxidation

Hydrolysis

Phosphorylation

4.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

What is the role of the signal peptide in insulin processing?

It is part of the mature insulin structure.

It signals the protein to remain in the cytosol.

It directs the protein to the rough ER lumen.

It helps in the formation of disulfide bridges.

5.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

Which enzyme is responsible for cleaving the signal peptide?

Ribosome

Prohormone Convertase

Carboxypeptidase E

SEC 11

6.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

What is the final step in the maturation of insulin?

Cleavage of the signal peptide

Translation of mRNA

Formation of disulfide bridges

Removal of C-terminal amino acids

7.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

What triggers the release of insulin into the blood?

The presence of glucagon

The amount of ATP in the cell

The concentration of sodium ions

The level of intracellular calcium