Wernicke’s Encephalopathy | Causes, Symptom Triad & Treatment

The video discusses Wernicke's Encephalopathy, an acute and reversible condition caused by a deficiency of vitamin B1 (thiamine). It highlights the common causes, such as chronic alcoholism and other conditions affecting nutritional absorption. The symptoms are summarized using the mnemonic 'CAN' for confusion, ataxia, and nystagmus. The pathophysiology involves thiamine's role in enzyme function, affecting energy metabolism. Treatment involves thiamine replacement, with a caution against administering glucose before thiamine. The video also warns about the potential development of Korsakoff syndrome if untreated.

What is the primary cause of Wernicke's encephalopathy?

• Vitamin B1 deficiency

• Vitamin C deficiency

• Vitamin B12 deficiency

• Vitamin D deficiency

Which group of people is most commonly affected by Wernicke's encephalopathy?

• Children

• Athletes

• Vegetarians

• Chronic alcoholics

What does the 'C' in the mnemonic 'CAN' stand for in relation to Wernicke's encephalopathy symptoms?

• Concentration

• Coordination

• Confusion

• Cerebellum

Which symptom is associated with oculomotor dysfunction in Wernicke's encephalopathy?

• Ataxia

• Confusion

• Hypotension

• Nystagmus

Which enzyme is NOT mentioned as being affected by thiamine deficiency in Wernicke's encephalopathy?

• Lactate dehydrogenase

• Pyruvate dehydrogenase

• Alpha ketoglutarate dehydrogenase

• Transketolase

What is the first step in treating Wernicke's encephalopathy?

• Administering glucose

• Administering thiamine

• Administering insulin

• Administering vitamin C

What chronic condition can develop if Wernicke's encephalopathy is not treated?

• Parkinson's disease

• Korsakoff syndrome

• Multiple sclerosis

• Alzheimer's disease