Endocannabinoids [Part 3] | Degradation of AEA & 2-AG

The video by Kevin Tokoph discusses the degradation pathways of endocannabinoids, specifically anandamide and 2-AG. It explains their retrograde action in regulating neurotransmitter release and details the enzymatic degradation process involving monoacylglycerol lipase and FAAH. The video also highlights the uptake and breakdown of these molecules in presynaptic and postsynaptic cells. The next video will explore endocannabinoids' role in cancer cell growth.

What is the primary action of endocannabinoids in neurotransmitter regulation?

• They inhibit neurotransmitter synthesis.

• They block neurotransmitter receptors.

• They act in a retrograde manner to regulate neurotransmitter release.

• They enhance neurotransmitter release.

Which enzyme is responsible for degrading 2-AG in the presynaptic cell?

• Lipoxygenase

• Fatty acid amido hydrolase

• Monoacylglycerol lipase

• Acetylcholinesterase

Where is anandamide primarily degraded?

• In the presynaptic cell

• In the postsynaptic cell

• In the synaptic cleft

• In the extracellular matrix

What is the main product of anandamide degradation?

• Glycerol

• Ethanolamine

• Phosphatidyl ethanolamine

• Arachidonic acid

What will be discussed in the next video regarding endocannabinoids?

• Their impact on cancer cell growth

• Their role in neurotransmitter synthesis

• Their effect on synaptic plasticity

• Their influence on mood regulation