Polyol Pathway & Diabetes | The Role of Polyol Pathway in Diabetes Pathogenesis

The video explains the polyol pathway, its role in converting glucose to sorbitol and then to fructose, and its significance in diabetes. It highlights the pathway's activation under high glucose levels and its importance in spermatocytes. The video also discusses the adverse effects of sorbitol accumulation in tissues with low sorbitol dehydrogenase activity, leading to diabetic complications like retinopathy, nephropathy, and neuropathy. Understanding this pathway helps in comprehending diabetes pathogenesis.

What is the primary function of the polyol pathway?

• To convert fructose to glucose

• To convert sorbitol to glucose

• To convert glucose to sorbitol

• To convert glucose to glycogen

Which enzyme is responsible for converting sorbitol to fructose?

• Glucose-6-phosphate dehydrogenase

• Aldose reductase

• Hexokinase

• Sorbitol dehydrogenase

Why is the polyol pathway particularly important in spermatocytes?

• Spermatocytes use sorbitol as their main energy source

• Spermatocytes use fructose as their main energy source

• Spermatocytes do not require energy from carbohydrates

• Spermatocytes use glucose as their main energy source

What is a major consequence of sorbitol accumulation in tissues?

• Decreased osmotic pressure

• Significant osmotic effects leading to tissue damage

• Improved glucose metabolism

• Increased energy production

Which part of the body is NOT mentioned as being affected by low sorbitol dehydrogenase activity?

• Retina

• Liver

• Kidney

• Nerves