Hilde Mangold and the Organizer of Life | Great Minds

The transcript discusses the foundational contributions to developmental biology, focusing on the work of Hans Spemann and Hilde Mangold. Mangold's thesis work in Spemann's lab led to the discovery of the 'Spemann organizer,' a key concept in developmental biology. Despite her significant contributions, Mangold received little credit, as she died before the publication of their results. Spemann won the Nobel Prize for this work, which remains a cornerstone of the field.

Who was the graduate student whose thesis work contributed significantly to Hans Spemann's Nobel Prize?

• Marie Curie

• Rosalind Franklin

• Barbara McClintock

• Hilde Mangold

What was the main focus of Spemann and Mangold's experiments in the early 1920s?

• The impact of environmental signals on cell division

• The concept of a developmental organizer

• The role of antibiotics in embryo development

• The genetic differences in amphibian species

What was the outcome when the dorsal lip was transplanted to a different region of the embryo?

• The embryo developed normally

• The embryo died

• The embryo developed twin larvae

• The embryo showed no change

What did the transplantation experiments reveal about the dorsal lip?

• It was not an organizer region

• It was responsible for infection

• It acted as an organizer, influencing surrounding tissues

• It had no effect on the host embryo

How many of Mangold's embryos survived the microsurgeries to be included in the publication?

• Ten

• Twenty

• Three

• Six

Why was Hilde Mangold's name not included on the Nobel Prize awarded to Spemann?

• She declined the recognition

• Nobel Prizes are not awarded posthumously

• She was not involved in the research

• Her work was not considered significant

What is the historical name given to the discovery made by Spemann and Mangold?

• Spemann's Law

• The Mangold Effect

• The Spemann Organizer

• Mangold's Principle