Prions | Mechanism of Kuru & Relation to Creutzfeldt-Jakob Disease

The video discusses kuru, a prion disease similar to Creutzfeldt-Jakob Disease (CJD), but transmitted through cannibalism. It explains the role of prion proteins, their misfolding, and how kuru spreads in Papua New Guinea. The disease primarily affects the cerebellum, leading to severe neurological symptoms and eventual death. Public health efforts have significantly reduced kuru cases by educating the population about the dangers of consuming infected brains.

What is the primary difference between Kuru and classical Creutzfeldt-Jakob Disease (CJD)?

• CJD is transmitted through air.

• Kuru requires an external source of prion proteins.

• Kuru is caused by a virus.

• CJD affects only animals.

What is the non-infectious form of the prion protein called?

• PRP A

• PRP B

• PRP C

• PRP SC

How do infectious prion proteins differ structurally from non-infectious ones?

• They have more beta strands.

• They are more soluble.

• They are smaller in size.

• They have more alpha helices.

How was Kuru primarily transmitted among the tribes in Papua New Guinea?

• Through insect bites.

• Through cannibalism.

• Through contaminated water.

• Through air droplets.

What part of the brain is mainly affected by Kuru?

• Cerebellum

• Cerebrum

• Brainstem

• Hippocampus

What is the ultimate cause of death in individuals with Kuru?

• Liver failure

• Heart failure

• Secondary infections

• Neurological deficits

What was the initial source of Kuru in Papua New Guinea?

• A person with classical CJD

• A contaminated water source

• An infected animal

• A viral outbreak

What efforts helped reduce the incidence of Kuru in Papua New Guinea?

• Educational campaigns

• Improved sanitation

• Vaccination programs

• Quarantine measures

What is variant Creutzfeldt-Jakob Disease (vCJD) associated with?

• Consumption of infected beef

• Consumption of infected poultry

• Consumption of infected fish

• Consumption of contaminated water

How is variant Creutzfeldt-Jakob Disease (vCJD) similar to Kuru?

• Both are caused by viruses.

• Both involve prion proteins from external sources.

• Both are transmitted through air.

• Both affect only animals.