Bronchodilators Part 2: Mechanisms of Action

What is the primary method of administering Salbutamol for treating pulmonary diseases?

• Topical application

• Inhalation through an inhaler

• Intravenous injection

• Oral tablets

Which receptor does Salbutamol primarily target to achieve bronchodilation?

• M3 muscarinic receptor

• Nicotinic receptor

• Beta 2 adrenergic receptor

• Alpha 1 adrenergic receptor

What is the role of protein kinase A in the mechanism of beta 2 adrenoceptor agonists?

• It activates myosin light chain kinase

• It dephosphorylates myosin light chain

• It inhibits adenylate cyclase

• It phosphorylates myosin light chain

How does beta 2 adrenoceptor stimulation affect intracellular calcium levels?

• Has no effect on calcium levels

• Fluctuates calcium levels

• Decreases calcium levels

• Increases calcium levels

Which muscarinic receptor subtype is most relevant in the context of bronchodilators?

• M1

• M2

• M3

• M4

What is the effect of muscarinic receptor antagonists on airway smooth muscle cells?

• Decrease relaxation

• Increase contractility

• No effect

• Enhance relaxation

What endogenous compound activates muscarinic receptors?

• Dopamine

• Acetylcholine

• Serotonin

• Histamine