Can a person feel no pain? (Congenital insensitivity to pain: CIP)

The video explores the concept of physical pain, highlighting its protective role despite being underappreciated. It introduces congenital insensitivity to pain (CIP), a rare disorder where individuals cannot feel pain, leading to severe injuries. The biological mechanism of pain involves nociceptors and sodium channels, with a genetic mutation in SCN9A causing CIP. The disorder is inherited in an autosomal recessive manner. Symptoms include unnoticed injuries, and diagnosis relies on clinical history and genetic testing. Current treatments like naloxone show promise, and future gene therapy may offer a cure.

Why is physical pain considered a protective mechanism?

• It makes us stronger.

• It is a sign of good health.

• It helps us avoid dangerous situations.

• It allows us to feel pleasure.

What role do nociceptors play in the perception of pain?

• They are responsible for emotional responses.

• They block pain signals from reaching the brain.

• They enhance the sensation of pleasure.

• They detect injuries and send signals to the brain.

What is the genetic cause of congenital insensitivity to pain (CIP)?

• A mutation in the gene responsible for emotional responses.

• An overproduction of pain-blocking chemicals.

• A deficiency in pain receptors.

• A mutation in the SCN9A gene affecting NaV1.7 channels.

How is CIP inherited?

• Through a dominant gene.

• As an autosomal recessive trait.

• Through a sex-linked gene.

• Via mitochondrial DNA.

What is one current treatment approach for CIP?

• Surgical removal of nociceptors.

• Using naloxone to increase pain sensitivity.

• Administering painkillers regularly.

• Gene therapy to replace the mutated gene.