Whipple Disease | Causes, Risk Factors, Pathophysiology, Symptoms, Diagnosis, Treatment

The video provides a comprehensive overview of Whipple disease, a rare systemic infection caused by the bacterium Tropheryma whipplei. It covers the disease's epidemiology, risk factors, pathophysiology, clinical features, diagnosis, and treatment. Whipple disease affects multiple bodily systems and presents with diverse symptoms, including gastrointestinal and neurological issues. Diagnosis involves recognizing classic symptoms and ruling out other conditions, followed by endoscopy and biopsy. Treatment includes an initial antibiotic phase followed by long-term maintenance to prevent relapse.

What is the causative agent of Whipple disease?

• Tropheryma whipplei

• Staphylococcus aureus

• Mycobacterium tuberculosis

• Escherichia coli

Which genetic factor is associated with an increased risk of Whipple disease?

• Factor V Leiden

• APOE ε4 allele

• BRCA1 mutation

• HLA-B27 haplotype

What is the primary issue in the pathophysiology of Whipple disease?

• Parasitic invasion

• Viral replication

• Bacterial toxin production

• Host immune response

Which symptom is NOT typically associated with Whipple disease?

• Migratory arthralgias

• Weight gain

• Diarrhea

• Abdominal pain

What is a classic symptom of Whipple disease affecting the joints?

• Joint dislocation

• Joint swelling

• Joint stiffness

• Migratory arthralgias

Which diagnostic method is commonly used to confirm Whipple disease?

• Ultrasound

• CT scan

• MRI scan

• Upper endoscopy with biopsy

What is the initial treatment phase for Whipple disease?

• Doxycycline for ten days

• Amoxicillin for one week

• Ceftriaxone or meropenem for two weeks

• Azithromycin for five days