Apoptosis | The Extrinsic Pathway

The video tutorial by Kevin Tolkoff explores the intrinsic and extrinsic pathways of apoptosis. It begins with a recap of the mitochondrial (intrinsic) pathway, highlighting the role of mitochondria in apoptosis. The focus then shifts to the extrinsic pathway, which requires external stimuli, often from immune cells. The video details the role of caspases, particularly caspase 8 and 3, in executing apoptosis. It also discusses the crosstalk between the extrinsic and mitochondrial pathways, emphasizing how proteins like bid facilitate this interaction, leading to complete cell death.

What role does the mitochondria play in the intrinsic pathway of apoptosis?

• It activates immune cells.

• It repairs DNA damage.

• It prevents the release of apoptotic proteins.

• It releases proteins that initiate apoptosis.

Which receptor is involved in the extrinsic pathway of apoptosis?

• BCL receptor

• FAS receptor

• Caspase receptor

• Diablo receptor

What is the function of caspase 8 in the apoptosis process?

• It repairs cell membranes.

• It acts as an initiator caspase.

• It directly degrades DNA.

• It inhibits apoptosis.

How does caspase 3 contribute to apoptosis?

• By blocking apoptotic bodies.

• By repairing DNA.

• By serving as an executioner caspase.

• By inhibiting other caspases.

What is the role of IAP in a healthy cell?

• It degrades DNA.

• It promotes apoptosis.

• It inhibits apoptosis.

• It activates caspase 8.

What does the protein Bid do in the apoptosis pathways?

• It inhibits the extrinsic pathway.

• It links the extrinsic and mitochondrial pathways.

• It repairs mitochondrial damage.

• It activates immune cells.

How does cancer affect the extrinsic pathway of apoptosis?

• It activates mitochondrial proteins.

• It enhances the expression of FAS inhibitors.

• It stops the expression of FAS inhibitors.

• It repairs DNA damage.

What is the main difference between the mitochondrial and extrinsic pathways of apoptosis?

• The mitochondrial pathway requires external stimuli.

• The extrinsic pathway is activated by DNA damage.

• The mitochondrial pathway is intrinsic and does not require external stimuli.

• The extrinsic pathway is independent of immune cells.

Which cells are typically involved in triggering the extrinsic pathway of apoptosis?

• Muscle cells

• Neurons

• Cytotoxic lymphocytes

• Red blood cells

What happens when the FAS ligand binds to the FAS receptor in cancerous cells?

• The cell divides uncontrollably.

• The cell becomes immune to apoptosis.

• The cell undergoes apoptosis.

• The cell repairs its DNA.