How do Melanocytes Make Melanin?: Melanogenesis Mechanism

The video explains how keratinocytes receive increased pigmentation through melanin production when exposed to sunlight, leading to tanning. It details the structure of skin layers, the role of keratinocytes and melanocytes, and the process of melanin production triggered by UV light. The protective role of melanin in shielding DNA from UV damage is highlighted, along with the differences in baseline melanin levels among ethnicities.

What is the primary function of keratinocytes in the skin?

• To produce melanin

• To absorb nutrients

• To protect the skin from UV radiation

• To produce keratin

What triggers the production of POMC in keratinocytes?

• DNA damage from UV light

• Increased melanin production

• Contact with water

• Exposure to cold temperatures

Which receptor does alpha-MSH bind to on melanocytes?

• MC1R

• P53

• POMC

• Keratin

Where is melanin synthesized within the melanocyte?

• In the cytoplasm

• In the melanosome

• In the cell membrane

• In the nucleus

How does melanin protect the DNA in keratinocytes?

• By increasing the thickness of the skin

• By converting UV light into visible light

• By absorbing UV light and dissipating it as heat

• By reflecting UV light

What is the main reason for different baseline levels of melanin among ethnicities?

• Different levels of melanocyte activity

• Different exposure to sunlight

• Different numbers of melanocytes

• Different skin thickness

What happens to melanosomes once they are inside keratinocytes?

• They disintegrate

• They release melanin pigments

• They remain static

• They produce more melanin