Chronic Lymphocytic Leukemia (CLL): Symptoms (ex. Skin Blisters), Diagnosis and Treatment (Vit D?)

The video tutorial provides an in-depth overview of Chronic Lymphocytic Leukemia (CLL), a type of blood cancer involving mature B cells. It covers the epidemiology, risk factors, clinical presentation, diagnosis, staging, treatment, and prognosis of CLL. The tutorial explains that CLL is common in older adults, particularly males, and often presents with symptoms like lymphadenopathy and splenomegaly. Diagnosis involves flow cytometry, and staging uses the modified Rye system. Treatment varies based on symptoms and genetic factors, with a watch-and-wait approach for asymptomatic patients.

What distinguishes CLL from SLL?

• CLL involves lymph nodes, SLL involves blood

• Both involve only blood

• CLL involves blood, SLL involves lymph nodes

• Both involve only lymph nodes

Which demographic is most commonly affected by CLL?

• Older males in Western countries

• Older females in South America

• Young females in Asia

• Young males in Africa

What is the most common physical finding in CLL?

• Lymphadenopathy

• Skin rashes

• Splenomegaly

• Hepatomegaly

Which symptom is least likely to occur in CLL?

• Severe joint pain

• Unintentional weight loss

• Drenching night sweats

• Extreme fatigue

What is the primary method for diagnosing CLL?

• MRI scan

• Ultrasound

• Flow cytometry

• X-ray

What is the threshold of B lymphocytes per microliter for diagnosing CLL?

• 1000

• 3000

• 7000

• 5000

What is the initial approach for treating asymptomatic CLL patients?

• Watch and wait

• Immediate chemotherapy

• Radiation therapy

• Surgical intervention

Which mutation requires the use of ibrutinib in CLL treatment?

• TP53 mutation

• EGFR mutation

• KRAS mutation

• BRCA1 mutation

What supplements have been shown to reduce the progression of CLL?

• Vitamin C and zinc

• Vitamin D and calcium

• Iron and magnesium

• Omega-3 and vitamin E

What is the median survival for early-stage asymptomatic CLL?

• 15 years

• 10 years or more

• 5 years

• 2 years