Biosignaling - Receptor Desensitization by Beta-arrestin

The video tutorial covers the concepts of activation and inactivation in signaling pathways, focusing on the desensitisation mechanism in G protein-coupled receptors. It explains how desensitisation affects drug tolerance, particularly in opioid addiction, and how it relates to smell adaptation. The tutorial also explores the interaction between insulin and G protein-coupled receptors, highlighting synergistic and antagonistic effects.

What happens to G protein coupled receptors during the process of endocytosis?

What implications does desensitization have in the context of drug withdrawal?

In what way do insulin and epinephrine have antagonistic functions?