Adenosine Deaminase Deficiency (Part 1) How Does dATP Accumulate

The video explores purine metabolism, focusing on adenosine deaminase and its broad specificity. It discusses the consequences of adenosine deaminase deficiency, leading to deoxy ATP accumulation and inhibition of ribonucleotide reductase. This inhibition affects DNA synthesis and the immune response. The video explains equilibrium reactions and Le Chatelier's principle in the context of deoxy ATP production, highlighting the importance of understanding these biochemical processes.

What are the potential pathways for hypoxanthine in purine metabolism?

How does the principle of equilibrium apply to the reactions involving deoxy adenosine?

What is the role of ribonucleotide reductase in nucleotide metabolism?

Discuss the impact of adenosine deaminase deficiency on the immune response.