Lectin Pathway of Complement Activation

The video explains the classical and lectin pathways of complement activation, emphasizing the role of antibodies in the classical pathway and the use of mannose-binding lectin (MBL) in the lectin pathway. MBL binds to sugars on pathogen surfaces, activating MASP, which then splits C4 and C2, leading to the formation of C3 and C5 convertases. This process ultimately results in the formation of the membrane attack complex (MAC), which disrupts the pathogen's membrane. The video also highlights the similarities and differences between the classical and lectin pathways, with a brief mention of the alternative pathway to be covered in a subsequent video.

What is the classical pathway of complement activation and how does it differ from the lectin pathway?

Evaluate responses using AI:

OFF

Discuss the role of sugars on the surface of pathogens in the activation of the lectin pathway.

Evaluate responses using AI:

OFF

Explain the role of mannose binding lectin (MBL) in the lectin pathway of complement activation.

Evaluate responses using AI:

OFF

What is the significance of the serine proteases associated with mannose binding lectin?

Evaluate responses using AI:

OFF

Describe the process that occurs when mannose binding lectin binds to mannose residues on a pathogen's surface.

Evaluate responses using AI:

OFF

What is the function of the C3 convertase in the complement activation process?

Evaluate responses using AI:

OFF

How does the membrane attack complex (MAC) contribute to the destruction of pathogens?

Evaluate responses using AI:

OFF

What are the key differences between the classical pathway and the lectin pathway in terms of activation?

Evaluate responses using AI:

OFF

What happens to C4 and C2 after they are activated in the lectin pathway?

Evaluate responses using AI:

OFF

In what way does the alternative pathway of complement activation differ from the classical and lectin pathways?

Evaluate responses using AI:

OFF