Prions | Mechanism of Classical Creutzfeldt-Jakob Disease (cCJD)

The video discusses prion diseases, focusing on classical Creutzfeldt-Jakob Disease (CJD). It explains the misfolding of prion proteins, which leads to aggregation and severe effects on the nervous system, causing neuronal dysfunction and cell death. The video also covers the mechanisms of misfolding, the impact on the brain, and the fatal nature of these diseases. Additionally, it touches on the transmission of prion diseases through consumption, highlighting kuru and variant CJD as examples.

Discuss the genetic factors involved in the misfolding of prion proteins.

What is the significance of the term 'spongiform' in relation to prion diseases?

What are the potential outcomes for individuals diagnosed with classical Creutzfeldt-Jakob Disease?

How does the consumption of infected tissue relate to the transmission of prion diseases?