Classical Pathway of Complement Activation

The video explains the classical pathway of complement activation, emphasizing the role of antibodies. It details how antibodies bind to antigens, leading to the activation of complement proteins like C1, which then trigger a cascade involving C3 and C5 convertases. This cascade results in the formation of the membrane attack complex (MAC), which disrupts pathogen cell membranes. The video also compares the classical pathway with the lectin and alternative pathways, highlighting their differences and similarities.

Explain the process of C3 convertase formation and its function.

What is the significance of the thioester bond in complement proteins?

What is the membrane attack complex and how does it function to kill pathogens?

Compare the classical pathway with the lectin and alternative pathways of complement activation.