Delta-Aminolevulinate Synthase (ALA Synthase): Physiology, Biochemistry, and Organic Mechanism

The video tutorial explains the synthesis of heme, focusing on the role of delta aminolevulinic acid synthase (ALA synthase) as the committed step in the process. It discusses the enzyme's function, regulation, and the impact of its deficiency, which can lead to disorders like X-linked sideroblastic anemia. The tutorial also covers the enzyme's mechanism, highlighting the importance of pyridoxal phosphate and the regulation of ALA synthase by energy charge and other factors.

What is the significance of the porphyrin ring in heme synthesis?

How does iron deficiency affect the activity of Delta aminolevulinic acid synthase?

Discuss the allosteric regulation of Delta aminolevulinic acid synthase.

What are the steps involved in the mechanism of Delta aminolevulinic acid synthase?