NAD Biosynthesis

The video tutorial explores the biosynthesis of NAD and NADP, focusing on three main pathways: starting with nicotinamide, nicotinate, and quinolinic acid. It explains the chemical reactions and enzymes involved in each pathway, highlighting the importance of these cofactors in biochemical processes. The tutorial also discusses the neurotoxic effects of quinolinic acid and its role in NAD synthesis.

What is the first cofactor discussed in the video?

Describe the synthesis pathway of NAD.

What role does PRPP synthetase play in the synthesis of NAD?

Explain the significance of the anomeric carbon in the context of ribose sugars.

What is the function of nicotinamide phosphoryl transferase?

How is NADP+ generated from NAD?

What is the difference between nicotinamide and nicotinate?

Describe the pathway that leads to the synthesis of quinolinic acid.

Summarize the three pathways to synthesize NAD discussed in the video.

What are the potential effects of high levels of quinolinic acid?