Omega Oxidation for Fatty Acids

The video tutorial explains Omega oxidation, a fatty acid catabolic pathway, and its significance, especially when beta oxidation enzymes are defective. It occurs in the smooth ER of the liver and kidneys, primarily on medium-chain fatty acids. The process involves three steps: hydroxylation, oxidation to an aldehyde, and oxidation to a carboxylic acid, yielding NADH. The resulting dicarboxylic acid is ligated to Coenzyme A and undergoes beta oxidation, producing energy and intermediates like succinyl COA, which enters the citric acid cycle.

What are the three major fatty acid catabolic pathways mentioned in the text?

Explain the significance of Omega oxidation in humans with defective beta oxidation enzymes.

Describe the location where Omega oxidation occurs in the body.

What is the first step in the Omega oxidation pathway and what enzyme is involved?

How does the Omega carbon get oxidized in the Omega oxidation pathway?

What happens to the fatty aldehyde in the Omega oxidation process?

What is the final product of the Omega oxidation pathway before entering beta oxidation?