TED-Ed: The surprising reason our muscles get tired - Christian Moro

Muscle fatigue occurs not just due to lactic acid or energy depletion but also due to the muscle's response to brain signals. Muscle contraction involves motor neurons, acetylcholine, and ion exchange, creating an action potential that leads to contraction. ATP is crucial for energy and ion balance. Over time, ion depletion can prevent muscle contraction, but rest allows ions to replenish. Regular exercise delays fatigue by reducing ion depletion cycles and increasing muscle size and ATP stores.

What is the significance of ATP in muscle function?

Describe how regular exercise affects muscle fatigue.