Organic Chemistry Synthesis Challenge 5

The video tutorial explains the conversion of a 6-membered ring substrate to a 5-membered ring product with a ketone. The process involves two main steps: ozonolysis with reductive workup to open the ring and form a linear molecule, followed by an intramolecular aldol condensation to form the desired 5-membered ring. The tutorial emphasizes the importance of enolate chemistry and the thermodynamic favorability of forming a 5-membered ring. The instructor provides a clear, step-by-step guide to understanding the reaction mechanisms involved.

What factors make the formation of a five-membered ring more favorable than a six-membered ring?

How does the intramolecular reaction contribute to the efficiency of the reaction pathway?

What is the final product of the reaction sequence described in the text?