Nucleotide Metabolism | Regulation of Purine Biosynthesis

The video tutorial covers the biosynthesis of purines, focusing on the synthesis of IMP and its conversion into AMP and GMP. It explains the regulation of these pathways, highlighting the role of allosteric enzymes like adenylyl succinate synthetase and IMP dehydrogenase. The tutorial also discusses the feedback inhibition mechanisms that balance purine levels in cells. Additionally, it covers the regulation of PRPP synthetase, emphasizing its role in nucleotide synthesis and how energy charge affects its activity. The video concludes with a summary of the key regulatory points in purine biosynthesis.

What happens to IMP levels when both AMP and GMP are elevated?

Discuss the role of allosteric regulation in the synthesis of purines.

How does ADP act as an inhibitor of PRPP synthetase?

What are the four regulatory points in purine biosynthesis?