NEW! Hexokinase Physiology, Biochemistry, and Mechanism

The video tutorial explores glycolysis, focusing on the role and mechanism of hexokinase. Glycolysis occurs in the cytosol, and hexokinase is crucial for glucose metabolism, acting as a committed step in pathways like glycogen synthesis and the pentose phosphate pathway. The enzyme's mechanism involves ATP binding and phosphorylation of glucose, facilitated by electrostatic interactions. Hexokinase's closed conformation prevents ATP hydrolysis, ensuring efficient catalysis. The enzyme's function is vital for retaining glucose in cells, preventing its re-entry into the bloodstream, and committing it to metabolic pathways.

What is the primary function of hexokinase in glucose metabolism?

What is the relationship between hexokinase and the pentose phosphate pathway?

Explain the significance of glucose 6 phosphate in metabolic pathways.

Explain the concept of a branch point in metabolic pathways using glucose 6 phosphate as an example.

Describe the mechanism by which hexokinase phosphorylates glucose.

What role does ATP play in the reaction catalyzed by hexokinase?

How does the closed confirmation of hexokinase prevent ATP hydrolysis?

Discuss the implications of high glucose levels in the blood and the role of hexokinase.

What are the consequences of glucose 6 phosphate not being able to cross the cell membrane?

What happens to glucose once it is phosphorylated by hexokinase?