Endocannabinoids [Part 2] | Major Mechanism of Action

The video by Kevin Tolkoff explores the mechanism of action of endocannabinoids, focusing on their synthesis from phospholipids and their role in regulating neurotransmitter release. It explains the committed step in endocannabinoid synthesis, the role of calcium in activating NaCl transferase, and the negative feedback mechanism to prevent excitotoxicity. The video also covers synaptic transmission, enzymatic pathways, retrograde signaling, and the regulation of neurotransmitter release through G protein-coupled receptors.

How do endocannabinoids prevent excitotoxicity in the central nervous system?

Explain the retrograde signaling mechanism of endocannabinoids.

What is the effect of G proteins on voltage-gated calcium and potassium channels?