Urate Oxidase and Urate (Part 2): Physiology, Gout, and Kidney Stones

The video explores urate oxidase, an enzyme not expressed in humans, and its role in purine catabolism. It explains the weak acid nature of uric acid, its solubility issues, and the equilibrium between urate and uric acid. The video discusses hyperuricemia, gout, and the role of proteins like SLC 2A9 in urate reabsorption. It details the crystallization process of uric acid, leading to painful conditions like gout and kidney stones. The video concludes with a preview of the next topic on uric acid's role as a free radical scavenger.

What role do the proteins in the nephron play in the regulation of uric acid levels?

What is the significance of the SLC 2A9 protein in uric acid metabolism?

Explain the crystallization process of uric acid and its relation to gout.

Discuss the relationship between uric acid and free radicals in the context of human health.