Nucleotide Metabolism | Degradation of IMP, AMP, & GMP

The video explains the degradation pathways of purine nucleotides IMP, GMP, and AMP, focusing on their conversion to xanthine and eventually uric acid. It highlights the role of enzymes like 5 prime nucleotidase and xanthine oxidase in these processes. The absence of urate oxidase in humans is discussed, linking it to evolutionary advantages and the antioxidant role of uric acid. The video also touches on the implications of uric acid accumulation, such as gout.

How does the degradation pathway of GMP differ from that of AMP?

What is the final common pathway for the degradation of purine nucleotides?

Discuss the implications of uric acid not being further degraded in humans.

What are the potential consequences of high uric acid levels in the body?