Biosignaling - G-protein-coupled Receptors PLC, DAG, & IP3

The video tutorial explains the G protein-coupled receptor pathways, focusing on the divergence from the adenylate cyclase pathway to the phospholipase C pathway. It details the signal transduction mechanism, the role of phospholipase C in hydrolyzing PIP2 into DAG and IP3, and the subsequent release of calcium ions from the endoplasmic reticulum. The activation of protein kinase C by DAG and calcium is discussed, leading to a phosphorylation cascade that results in a cellular response.

What is the role of G protein coupled receptors in cellular signaling?

Describe the process that occurs when a hormone binds to a G protein coupled receptor.

What are the two products generated when phospholipase C hydrolyzes PIP2?

Explain how IP3 affects calcium ion concentration in the cytosol.

What is the function of diacylglycerol (DAG) in the signaling pathway?

How does protein kinase C (PKC) become activated?

What is the significance of the phosphorylation cascade initiated by PKC?