tRNA "Funny Bases": More than 4 RNA bases?

The video tutorial explores the unique bases found in tRNA, such as pseudouridine, inosine, and thiouridine. It delves into the mechanisms of their synthesis, including the role of specific enzymes like pseudouridine synthase and adenosine deaminase. The tutorial also discusses the incorporation of thymine in RNA through methylation and the implications of these modifications on tRNA function. Additionally, it covers the process of prenylation and other modifications that contribute to the diverse properties of tRNA.

Discuss the importance of the nitrogen-carbon bond in uridine compared to the carbon-carbon bond in pseudo uridine.

What are the potential implications of adenosine deaminase deficiency?

How does the modification of adenine to inosine affect its function in tRNA?

What is the mechanism by which thiopurine synthetase modifies uridine?