ALA Synthase

The video explores the biosynthesis of heme, focusing on the synthesis of delta aminolevulinate, the committed step in heme production. It discusses the energetic costs of the process, the role of aminolevulinic acid synthase, and the regulation of heme synthesis through enzyme synthesis and allosteric inhibition by heme. The video also highlights the influence of barbiturates and steroids on enzyme activity, explaining why males have higher hemoglobin levels.

What is the structure of alpha amino beta keto adipate and its role in heme synthesis?

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Identify two molecules that can speed up the synthesis of aminolevulinic acid synthase.

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How does the presence of steroids with a double bond at carbon #4 affect aminolevulinic acid synthesis?

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What is the final product of the heme synthesis pathway that is regulated by aminolevulinic acid synthase?

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