Huntington's Disease and Protein Interactions

The video explores Huntington's disease, a genetic disorder affecting memory, movement, and life expectancy. It explains the role of the Huntington protein in cell transport, protein synthesis, and apoptosis prevention. The disease results from abnormal protein shapes due to genetic mutations, leading to cell damage. Current research focuses on enhancing protein degradation systems to treat the disease.

What is the primary function of the HTT gene?

• To code for the huntingtin protein

• To regulate cell apoptosis

• To produce neurotransmitters

• To synthesize RNA

Which proteins does huntingtin interact with to assist in cell transport?

• Tubulin and dynein

• Keratin and collagen

• Elastin and fibrin

• Actin and myosin

How does huntingtin protein promote the production of BDNF?

• By inhibiting protein degradation

• By enhancing DNA replication

• By increasing RNA synthesis

• By binding to a repressor protein

What role does huntingtin play in preventing apoptosis?

• It inhibits caspase enzymes

• It enhances DNA repair

• It activates immune response

• It promotes cell division

What is the consequence of having extra CAG repeats in the HTT gene?

• Reduced RNA transcription

• Increased cell division

• Abnormal protein folding

• Enhanced protein synthesis

What is the role of the ubiquitin proteasome system (UPS) in cells?

• To destroy misfolded proteins

• To transport nutrients

• To replicate DNA

• To synthesize new proteins

How do protein aggregates affect the cell nucleus?

• They disrupt its ability to function

• They promote cell growth

• They enhance gene expression

• They increase RNA synthesis

What happens to the CBP protein in the presence of altered huntingtin?

• It promotes apoptosis

• It enhances cell survival

• It is captured and removed from its location

• It increases protein synthesis

Why might Huntington's disease symptoms appear later in life?

• Immediate genetic mutation effects

• Rapid cell division

• Gradual buildup of huntingtin proteins and aggregates

• Early onset of apoptosis

What is a potential area of research for treating Huntington's disease?

• Increasing RNA transcription rates

• Promoting cell apoptosis

• Enhancing the UPS to destroy aberrant proteins

• Reducing DNA replication errors