Urocanate Hydratase Mechanism

The video tutorial explores the catabolism of histidine, focusing on the enzyme urocanic hydratase. It explains the unique mechanism involving NAD and a carbon nucleophile, highlighting the rare sigmatropic rearrangement. The tutorial concludes with the addition reaction and the formation of imidazoline propionate, emphasizing the driving force of tautomerization due to enol instability.

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