How do antidepressants work? | Neil R. Jeyasingam

The video explores the history and development of antidepressants, starting with the accidental discovery of mood-improving effects in drugs like iproniazid and imipramine. This led to the chemical imbalance theory, suggesting depression is due to insufficient monoamines. The development of SSRIs, particularly Prozac, marked a significant advancement, offering targeted treatment with fewer side effects. Despite their success, the understanding of depression remains incomplete, with ongoing debates about the causes and treatment efficacy. The video emphasizes the complexity of depression and the need for a multifaceted treatment approach.

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