Peterson Olefination

The video tutorial explores the synthesis of alkenes, focusing on the Peterson olefination. This reaction, first described by Donald Peterson in 1968, involves metallating an alpha Halo Silane to form nucleophilic reagents that react with aldehydes or ketones. The process yields a beta hydroxy silane, which is then treated with acid or base to form an olefin. The coproduct, trimethyl silanol, is volatile and easily removed. The tutorial discusses stereochemistry, selectivity, and the reaction's applications in synthesizing natural products.

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