Tuberculosis Protein: Key to Understanding "Gene Switch"

The video discusses a protein from the microbe causing tuberculosis, focusing on its structure and function. The protein, CRP, is made of two subunits and binds cyclic AMP, which signals it to activate genes necessary for bacterial survival. Unlike most proteins with two subunits, this one is asymmetric, particularly in the DNA-binding region. The video explores how the protein switches from an off to an on state, triggered by cyclic AMP, and the scientific implications of understanding this mechanism for developing strategies against tuberculosis and other pathogens.

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