Corrin/B12 Biochemistry: Methylmalonyl-S-CoA Mutase Mechanism

The video explains the beta oxidation of odd-chain fatty acids, focusing on the conversion of propionyl CoA to succinyl CoA through a short catabolic pathway. It highlights the role of adenosylcobalamin, a derivative of vitamin B12, in the methylmalonyl CoA mutase reaction. The mechanism involves radical formation and hydrogen abstraction, ultimately leading to the production of succinyl CoA, which enters the TCA cycle. The video is part of a series on fat oxidation and B12 biochemistry.

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