Parkinson's Disease [Part 2] | Detailed Mechanism with Basal Nuclei

The video explains how Parkinson's disease affects the basal nuclei, focusing on the direct and indirect pathways. It describes the normal function of these pathways and how dopamine modulates them. The direct pathway promotes movement, while the indirect pathway suppresses unwanted movement. Dopamine enhances movement by modulating both pathways. In Parkinson's, the degeneration of the substantia nigra reduces dopamine, leading to less movement and symptoms like bradykinesia.

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