Paroxysmal Nocturnal Hemoglobinuria (PNH) | Causes & Pathogenesis, Symptoms, Diagnosis & Treatment

The video tutorial explains paroxysmal nocturnal hemoglobinuria (PNH), a rare acquired blood disorder affecting hematopoietic stem cells due to a piga gene mutation. It covers the pathophysiology involving complement activation leading to hemolysis, clinical features like hemoglobinuria and anemia, and complications such as thrombosis. Diagnosis is primarily through flow cytometry, and treatment includes eculizumab and anticoagulation. The tutorial also highlights the risk of PNH transforming into other blood disorders.

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