Proteasome Mechanism: Threonine Hydrolysis

The video explains the mechanism of the 26S proteasome, which degrades damaged proteins in cells. It covers the structure and function of the proteasome, highlighting the role of ATP hydrolysis in unfolding proteins. The catalytic mechanism involves a threonine residue and catalytic water, differing from typical serine proteases by not using a histidine residue. The process generates peptides, not individual amino acids, which are further recycled.

What new insight or understanding did you gain from this video?