McMurry Reaction

The video tutorial discusses olefination reactions, focusing on the McMurray reaction, a method for synthesizing alkenes through reductive coupling of carbonyl compounds. It highlights the reaction's mechanism, involving titanium species and ketol radicals, and addresses challenges like E/Z selectivity. The McMurray reaction's applications in intramolecular reactions and natural product synthesis are explored, along with its limitations in controlling product distribution. The tutorial also covers the reaction's extensions to other carbonyl compounds and its suitability for synthesizing strained olefins.

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