Can a person feel no pain? (Congenital insensitivity to pain: CIP)

The video explores the concept of physical pain, highlighting its protective role despite being underappreciated. It introduces congenital insensitivity to pain (CIP), a rare disorder where individuals cannot feel pain, leading to severe injuries. The biological mechanism of pain involves nociceptors and sodium channels, with a genetic mutation in SCN9A causing CIP. The disorder is inherited in an autosomal recessive manner. Symptoms include unnoticed injuries, and diagnosis relies on clinical history and genetic testing. Current treatments like naloxone show promise, and future gene therapy may offer a cure.

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