Understanding p53 and Its Role in Cancer Prevention

What is the primary role of the p53 gene in cells?

• To promote cell division

• To suppress tumor formation

• To enhance DNA replication

• To increase protein synthesis

How does mdm2 regulate p53 in cells without DNA damage?

• By phosphorylating p53

• By stabilizing p53

• By marking p53 for degradation

• By enhancing p53 transcription

What happens to p53 when DNA damage occurs?

• It is exported out of the cell

• It is degraded by mdm2

• It is converted into a different protein

• It is phosphorylated and accumulates

Which protein does p53 induce to halt the cell cycle?

• Cyclin A

• RB

• p21

• CDK4

What are the potential outcomes if DNA damage is too extensive to be repaired?

• Increased cell growth

• Enhanced DNA repair

• Permanent cell cycle arrest or apoptosis

• Cell cycle progression