Tranexamic Acid in Critical Care

What is the primary role of tranexamic acid in critical care?

• To reduce heart rate

• To increase blood pressure

• To stop bleeding by preventing clot breakdown

• To promote clotting

Which study highlighted the importance of timing in administering tranexamic acid?

• MATTERS

• CRASH-2

• PLATO

• RE-LY

What is the mechanism by which tranexamic acid works?

• It increases platelet aggregation

• It prevents the breakdown of fibrin clots

• It promotes the formation of new clots

• It inhibits the conversion of fibrinogen to fibrin

How does tranexamic acid compare to aminocaproic acid?

• It is less potent

• It has the same potency

• It is eight times more potent

• It is not comparable

Which of the following is a potential side effect of tranexamic acid?

• Renal failure

• Hyperglycemia

• Increased risk of thrombotic events

• Hypertension

What is the initial IV dose of tranexamic acid for trauma patients?

• 2 grams in 200 mL over 20 minutes

• 1 gram in 100 mL over 10 minutes

• 1.5 grams in 150 mL over 15 minutes

• 500 mg in 50 mL over 5 minutes

In which scenario is tranexamic acid NOT typically beneficial?

• Gastrointestinal bleeding

• Massive transfusion protocol

• Postpartum hemorrhage

• Trauma

What is the recommended follow-up dose of tranexamic acid after the initial dose?

• 1 gram over 4 hours

• 1 gram over 8 hours

• 500 mg over 6 hours

• 2 grams over 12 hours

Which of the following is a common use of tranexamic acid in critical care?

• To reduce bleeding in cardiac surgery

• To manage hyperglycemia

• To prevent infections

• To treat hypertension

What is a key consideration when administering tranexamic acid?

• It should be given within 6 hours of injury

• It should be given within 3 hours of injury

• It should be given only to patients with a history of DVT

• It should be given rapidly to avoid hypotension