Tranexamic Acid in Critical Care

What is the primary role of tranexamic acid in critical care?

• To stop bleeding by preventing clot breakdown

• To promote clotting

• To reduce heart rate

• To increase blood pressure

When was tranexamic acid first discovered?

• 1982

• 1952

• 1972

• 1962

What was a significant finding of the CRASH-2 study regarding tranexamic acid?

• It had no effect on mortality

• It decreased mortality when given within three hours of injury

• It was only effective in surgical patients

• It increased mortality in trauma patients

How does tranexamic acid function as an anti-fibrinolytic agent?

• By increasing platelet aggregation

• By inhibiting the breakdown of fibrin clots

• By preventing the conversion of fibrinogen to fibrin

• By promoting the formation of new clots

Which receptor does tranexamic acid bind to in order to prevent fibrin breakdown?

• Serotonin receptor

• Lysine receptor

• Histamine receptor

• Dopamine receptor

What is a common side effect of tranexamic acid?

• Nausea and vomiting

• Hair loss

• Increased appetite

• Hypertension

In which patient population should tranexamic acid be used cautiously due to the risk of thrombotic events?

• Patients with a history of DVT or PE

• Patients with diabetes

• Patients with hypertension

• Patients with asthma

What is the initial IV dose of tranexamic acid for trauma patients?

• 1 gram in 100 mL over 10 minutes

• 500 mg in 50 mL over 5 minutes

• 2 grams in 200 mL over 20 minutes

• 3 grams in 300 mL over 30 minutes

For which condition is tranexamic acid NOT found to be beneficial according to studies?

• GI bleeding

• Postpartum hemorrhage

• Cardiac surgery

• Trauma

What is a unique feature of tranexamic acid compared to other similar medications?

• It is more expensive than other options

• It is only available in oral form

• It has eight times the activity of aminocaproic acid

• It is a natural compound